The beginning of the GLP-1 agonist revolution
What is SEMA GLP-1 (S)?
SEMA GLP-1 (S) is a synthetic analogue of the human GLP-1 hormone, designed to bind and activate the GLP-1 receptor. This activation promotes glucose-dependent insulin secretion and inhibits glucagon release, aiding in blood sugar regulation. Additionally, SEMA GLP-1 (S) slows gastric emptying, leading to increased satiety and potential weight loss. Due to its extended half-life, SEMA GLP-1 (S) is administered once weekly, offering a convenient dosing regimen for research purposes. This compound is intended solely for scientific investigation and is not approved for human or veterinary use.
Structure
- Chemical Formula: C₁₈₇H₂₉₁N₄₅O₅₉
- Synonyms: NN9535, Ozempic, Rybelsus, Wegovy
SEMA GLP-1 (S) Research
SEMA GLP-1 (S) in Type 2 Diabetes Management
Clinical trials have demonstrated that SEMA GLP-1 (S) significantly improves glycemic control in individuals with type 2 diabetes. In the SUSTAIN-6 trial, SEMA GLP-1 (S) reduced HbA1c levels and was associated with a lower rate of major adverse cardiovascular events compared to placebo. These findings suggest its potential role in comprehensive diabetes management. [1]
SEMA GLP-1 (S) and Weight Management
Research indicates that SEMA GLP-1 (S) may be effective in promoting weight loss among individuals with obesity. A study published in The New England Journal of Medicine reported that participants receiving SEMA GLP-1 (S) experienced significant weight reduction compared to those on placebo. This effect is attributed to its action on appetite regulation and energy intake. [2]
Cardiovascular Outcomes with SEMA GLP-1 (S)
SEMA GLP-1 (S) has been evaluated for its impact on cardiovascular outcomes in patients with type 2 diabetes. The SUSTAIN-6 trial demonstrated a significant reduction in the risk of major adverse cardiovascular events among participants treated with SEMA GLP-1 (S). These results highlight its potential cardiovascular benefits beyond glycemic control. [3]
SEMA GLP-1 (S) and Non-Alcoholic Steatohepatitis (NASH)
Emerging studies suggest that SEMA GLP-1 (S) may have therapeutic potential in treating non-alcoholic steatohepatitis (NASH). Clinical trials have shown improvements in liver enzyme levels and reductions in liver fat content among patients with NASH treated with SEMA GLP-1 (S), indicating a possible role in managing this condition. [4]
GLP-1 (S) / SEMA / Semaglutide is typically reconstituted with Bacteriostatic water at 5mg/ml to 10mg/ml. Dosing varies widely depending on the individual, their experience with GLP-1 agonists and how quickly they want to achieve fat loss. Because GLP-1 (S) is an older, less refined peptide, we recommend that users start with 250mcg/wk to avoid negative side effects. Most users will follow a titration schedule. In our experience working with clients, rather than continuing to titrate up to higher and higher doses, we encourage users to switch over to GLP-2 (T) or GLP-3 (R) as their progress slows and they find they need a higher dose to continue to achieve results.
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Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
Referenced Citations
- Marso SP, Daniels GH, Brown-Frandsen K, et al. “SEMA GLP-1 (S) and Cardiovascular Outcomes in Patients with Type 2 Diabetes.” The New England Journal of Medicine. 2016;375(19):1834–1844. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa1607141
- Wilding JPH, Batterham RL, Calanna S, et al. “Once-Weekly SEMA GLP-1 (S) in Adults with Overweight or Obesity.” The New England Journal of Medicine. 2021;384(11):989–1002. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa2032183
- Marso SP, Bain SC, Consoli A, et al. “SEMA GLP-1 (S) and Cardiovascular Outcomes in Patients with Type 2 Diabetes.” The New England Journal of Medicine. 2016;375(19):1834–1844. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa1607141
- Newsome PN, Buchholtz K, Cusi K, et al. “A Placebo-Controlled Trial of Subcutaneous SEMA GLP-1 (S) in Nonalcoholic Steatohepatitis.” The New England Journal of Medicine. 2021;384(12):1113–1124. Available at: https://www.nejm.org/doi/full/10.1056/NEJMoa2028395
