What is SLU-PP-332?
SLU-PP-332 is a synthetic compound designed to activate estrogen-related receptors (ERRs), particularly ERRα. These nuclear receptors are involved in regulating metabolic pathways, including mitochondrial biogenesis and energy metabolism. By modulating ERR activity, SLU-PP-332 has been investigated for its potential to mimic exercise-induced metabolic benefits, such as increased fatty acid oxidation and improved endurance. This compound is intended solely for scientific investigation and is not approved for human or veterinary use.
Structure
- Chemical Formula: C₁₈H₁₄N₂O₂
- Synonyms: 4-hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide
SLU-PP-332 Research
SLU-PP-332 and Mitochondrial Function
In vitro studies have demonstrated that SLU-PP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. Treatment with SLU-PP-332 increased the expression of pyruvate dehydrogenase kinase 4 (Pdk4), a target gene of ERRs involved in energy metabolism. Additionally, it boosted mitochondrial respiration in C2C12 myocytes, indicating a potential role in improving cellular energy production.
SLU-PP-332 and Exercise Endurance
Animal studies have explored the impact of SLU-PP-332 on physical performance. In mice, administration of SLU-PP-332 increased the proportion of oxidative (Type IIa) muscle fibers and enhanced exercise endurance. These findings suggest that SLU-PP-332 may mimic certain adaptations associated with endurance training, potentially offering insights into muscle physiology and performance enhancement.
SLU-PP-332 and Metabolic Health
Research involving diet-induced obese mice has investigated the metabolic effects of SLU-PP-332. Treatment with the compound led to increased energy expenditure and fatty acid oxidation, resulting in reduced fat mass accumulation. Furthermore, SLU-PP-332 improved insulin sensitivity in models of metabolic syndrome, indicating potential applications in studying metabolic disorders such as obesity and type 2 diabetes.
For our free Peptide Calculator CLICK HERE
Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
Referenced Citations
- Billon C, Murray MH, Avdagic A, et al. “Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Metabolic Gene Signature and Enhances Exercise Capacity.” ACS Chemical Biology. 2023;18(4):839–849. Available at: https://pubmed.ncbi.nlm.nih.gov/36988910/
- Billon C, Murray MH, Avdagic A, et al. “A Synthetic ERR Agonist Alleviates Metabolic Syndrome.” Journal of Pharmacology and Experimental Therapeutics. 2024;379(3):301–312. Available at: https://pubmed.ncbi.nlm.nih.gov/37739806/
