What is AOD-9604?
AOD-9604 is a synthetic peptide fragment developed from the C-terminal end of human growth hormone (hGH), specifically residues 176-191. This sequence has been shown in research environments to promote lipolysis (fat breakdown) and inhibit lipogenesis without the typical growth-inducing effects associated with full-length hGH. It has been investigated for its ability to regulate fat metabolism, making it a key focus in studies related to obesity, metabolic function, and cartilage regeneration. It is stable, well-tolerated in preclinical models, and useful in targeted metabolic research.
AOD-9604 is a modified peptide designed to mimic the fat-reducing action of natural growth hormone’s fragment 176-191. It selectively promotes lipolytic activity, increasing fat oxidation without stimulating insulin secretion or muscle growth. Unlike full hGH, it does not impact blood glucose or IGF-1 levels, making it a specialized tool in metabolic and anti-obesity research. This peptide is provided in lyophilized powder form for laboratory use only.
Structure
- Chemical formula: C78H123N23O23S2
AOD-9604 is a 16-amino acid peptide fragment that represents the lipolytic region of hGH, modified to enhance stability and bioactivity in experimental settings.
Research
Obesity
Preclinical studies have shown that AOD-9604 stimulates the breakdown of stored fat (lipolysis) and inhibits the formation of new fat cells (lipogenesis). It acts on beta-adrenergic-like mechanisms to accelerate fat metabolism without increasing appetite or muscle mass. Importantly, it does not affect overall growth or IGF-1 levels. This selective activity makes it a promising candidate in obesity and weight-loss research, with a safety profile suitable for long-term metabolic studies.
Joint Pain and Function
Emerging research suggests that AOD-9604 may aid in cartilage repair and reduce joint inflammation. It has been observed to stimulate chondrocyte activity and matrix synthesis in lab models, indicating potential for improved joint function and reduced pain. These effects, combined with its anti-inflammatory profile, make it a peptide of interest in studies related to osteoarthritis, injury recovery, and age-associated joint degeneration.
Heart Disease
AOD-9604’s influence on lipid metabolism is being explored in the context of cardiovascular health. By enhancing fat breakdown and possibly improving lipid profiles, it may contribute to a reduced risk of conditions linked to metabolic syndrome and obesity. While its direct impact on cardiac tissue remains under investigation, its systemic fat-reducing capabilities present promising avenues for research into cardiovascular risk reduction.
Reconstitution and Dosing
AOD-9604 is prone to forming a gel when reconstituted with Bacteriostatic water alone. In order to properly reconstitute it without gelling, it is recommended that reconstitution be performed with a combination of Bacteriostatic water and Acetic Acid 0.6% in a 5:1 ratio of water to acetic acid. Concentration of the solution is recommended at 2 to 2.5mg/ml. Dosing is typically administered at 250-300mcg for 5 to 7 days per week.
For our free Peptide Calculator, CLICK HERE. Research-grade AOD-9604 is available from WellnessPeptides.
Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
