Bronchogen (H-Glu-Asp-Ala-OH) is a synthetic tripeptide, molecular weight ~291.27 Da (PubChem CID: 23678447). Classified as a short bioregulatory peptide, it has been studied in experimental models for its ability to regulate bronchial epithelial cell activity, gene expression, and extracellular signaling in respiratory research contexts.
Research Overview
- Structure and Molecular Characteristics
Bronchogen is a tripeptide consisting of glutamic acid, aspartic acid, and alanine. Its molecular formula is C₁₀H₁₇N₃O₈, with a molecular weight of 291.27 g/mol [1]. As a member of the class of synthetic short peptides, it is polar, water-soluble, and capable of interacting with cellular and nuclear proteins in respiratory tissue models [1].
- Respiratory Research
Bronchogen has been investigated in preclinical studies for its role in regulating the function of bronchial epithelial cells [2]. Research in aged and young animal models indicates that the peptide enhances proliferative and metabolic activity of these cells [2]. Unlike individual amino acids, which often show diminished activity in senescent cells, Bronchogen maintained consistent regulatory properties across different age groups, making it relevant for experimental studies into age-related respiratory decline [2].
- Gene Expression Studies
In bronchial epithelial cell cultures, Bronchogen has been shown to influence gene expression associated with protein synthesis, cellular metabolism, and extracellular signaling [3]. These include modulation of genes involved in structural proteins and enzymatic pathways. Such effects suggest its potential importance as a tool for research into peptide-mediated regulation of bronchial tissue biology [3].
- Fibroblast and Cytoskeletal Regulation
Experimental evidence suggests that Bronchogen influences structural protein expression, particularly cytoskeletal proteins like actin, tubulin, and vimentin [4]. These proteins contribute to cellular morphology, mechanical stability, and intracellular transport. Bronchogen’s ability to modulate these factors supports further studies into how synthetic peptides regulate fibroblast activity in respiratory tissues [4].
- Aging and Cellular Senescence Research
Bronchogen is also a subject of gerontology-focused studies. Investigations into aging respiratory systems demonstrate that the peptide may restore diminished signaling pathways and maintain cellular activity despite senescence [2][5]. This property has made it of interest in experimental biology, particularly for understanding peptide influences on age-related changes in bronchial tissue.
Reconstitution and dosing
Bronchogen is typical reconstituted with Bacteriostatic water in various concentrations, usually in 10mg/ml. Bronchogen is typically dosed at 2mg per day for 20 days and this protocol is followed 2-3 times per year for Lung health and support.
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Referenced Citations
- PubChem. Bronchogen. CID 23678447. PubChem
- Khavinson VKh, et al. Effect of short peptides on proliferation of bronchial epithelial cells in aging models. Bull Exp Biol Med. 2004. PubMed
- Khavinson VKh, et al. Short peptides regulate gene expression in bronchial epithelial cells. Bull Exp Biol Med. 2005. PubMed
- Khavinson VKh, et al. Bronchogen modulation of cytoskeletal protein synthesis in respiratory fibroblasts. Bull Exp Biol Med. 2006. PubMed
- Khavinson VKh, et al. Peptide regulation of age-related decline in bronchial epithelial cells. Bull Exp Biol Med. 2007. PubMed
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